Wednesday, November 30, 2011

Researchers examine role of inflammatory mechanisms in a healing heart

ScienceDaily (Nov. 30, 2011) ? Virginia Commonwealth University researchers have found that an inflammatory mechanism known as inflammasome may lead to more damage in the heart following injury such as a heart attack, pointing researchers toward developing more targeted strategies to block the inflammatory mechanisms involved.

Following a heart attack, an inflammatory process occurs in the heart due to the lack of oxygen and nutrients. This process helps the heart to heal, but may also promote further damage to the heart. The mechanisms by which the heart responds to injury are not fully understood, so researchers have been examining the cellular pathways involved to gain further insight.

In a study published online the week of Nov. 21 in the Proceedings of the National Academy of Sciences, researchers addressed the role of a specific inflammatory mechanism, called inflammasome, during the process of healing in the heart. Using an animal model, the team found that inflammasome amplifies the response by generating the production of a key inflammatory mediator known as Interleukin-1?. Further, they described that pharmacologic inhibition of the formation of inflammasome prevents heart enlargement and dysfunction.

"Defining the role of the inflammasome in the response to injury in the heart and the possibility to intervene opens a new area of investigation for the prevention and treatment of heart failure following a heart attack," said Antonio Abbate, M.D., assistant professor of medicine in the VCU Department of Internal Medicine and Division of Cardiology.

According to Abbate, who serves as the interim director for the cardiac intensive care unit at the VCU Pauley Heart Center, this study supports the team's previous findings that showed that Interleukin-1? affects the heart, and blocking Interleukin-1? benefits patients of heart attack and heart failure.

"Based on the findings of the current study we are even more convinced that blocking Interleukin-1? may be safe and beneficial, and we are now exploring novel ways to do so," he said.

Abbate said there are four ongoing clinical trials at the VCU Pauley Heart Center in patients with various heart conditions treated with a drug called anakinra which blocks Interleukin-1?.

Abbate and his team continue to examine the molecular mechanisms of inflammasome formation and heart injury, and hope to determine new ways to intervene with potentially more targeted strategies in the future.

The study was conducted in the Victoria W. Johnson Center for Research at VCU, which is directed by Norbert Voelkel, M.D, professor of medicine in the Pulmonary and Critical Care Division.

Abbate led with a multidisciplinary team of VCU researchers biologists, physicians, and pharmacists including Eleonora Mezzaroma, Ph.D., and Stefano Toldo, Ph.D., post-doctoral associates in the VCU Pauley Heart Center; Daniela Farkas, B.S., research specialist in the Victoria Johnson Research Laboratory; Benjamin Van Tassell, Pharm.D., assistant professor of pharmacology and outcome sciences; and Fadi Salloum, Ph.D., assistant professor of medicine and physiology in the VCU Pauley Heart Center.

This study was supported by a grant from the American Heart Association.

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The above story is reprinted from materials provided by Virginia Commonwealth University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. E. Mezzaroma, S. Toldo, D. Farkas, I. M. Seropian, B. W. Van Tassell, F. N. Salloum, H. R. Kannan, A. C. Menna, N. F. Voelkel, A. Abbate. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1108586108

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_TqTrHFswjQ/111130141859.htm

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HBT: Rays finally sign Jose Molina

This has been a long time coming ? it was first reported a couple of weeks ago ? but the Rays have finally signed Jose Molina. It?s a one-year deal for $1.8 million with a club option.

Of course, when this was first reported, Molina was supposed to be John Jaso?s backup. ?Jaso was traded to Seattle last night. ?If they?re interested in defense-first, Molina is a great option. But he has only caught 100 games in a season once in his career, so the Rays are still likely to snag another catcher. Ramon Hernandez? Go all-in with?Robinson Chirinos?

Hard to say, but now that there?s a Molina there, there is some semblance of stability. I mean, that?s what Molinas do.

Source: http://hardballtalk.nbcsports.com/2011/11/28/the-rays-sign-jose-molina/related/

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NKorea claims progress in uranium enrichment (AP)

SEOUL, South Korea ? North Korea said Wednesday that it is making rapid progress on work to enrich uranium and build a light-water nuclear power plant, increasing worries that the country is developing another way to make atomic weapons.

An unidentified spokesman at Pyongyang's Foreign Ministry said in a statement that the construction of an experimental light-water reactor and low enriched uranium are "progressing apace."

The statement, carried by the official Korean Central News Agency, said that North Korea has a sovereign right to the peaceful use of nuclear energy and that "neither concession nor compromise should be allowed."

Concerns about North Korea's atomic capability took on renewed urgency in November 2010 when the country disclosed a uranium enrichment facility that could give it a second route to manufacture nuclear weapons, in addition to its existing plutonium-based program.

North Korea has been building a light-water reactor at its main Yongbyon nuclear complex since last year. Such a reactor is ostensibly for civilian energy purposes, but it would give the North a reason to enrich uranium. At low levels, uranium can be used in power reactors, but at higher levels it can be used in nuclear bombs.

Earlier this month, North Korean state media said "the day is near at hand" when the reactor will come into operation. Washington worries about reported progress on the reactor construction, saying it would violate U.N. Security Council resolutions.

U.S. Secretary of State Hillary Rodham Clinton, speaking to reporters Wednesday at an international aid forum in the South Korean port city of Busan, didn't address the North's statement on uranium. She called the U.S.-South Korean alliance strong and mentioned the recent one-year anniversary of North Korea's artillery attack on a front-line South Korean island that killed four people.

"Let me reaffirm that the United States stands with our ally, and we look to North Korea to take concrete steps that promote peace and stability and denuclearization," Clinton said.

Five countries, including the United States, have been in on-again, off-again talks with North Korea to provide Pyongyang with aid in exchange for disarmament. North Korea pulled out of the nuclear disarmament talks in early 2009 to protest international condemnation of its prohibited long-range rocket test.

In recent months, North Korea has repeatedly expressed its willingness to return to the talks, and tensions between the Koreas have eased. Diplomats from the Koreas and the United States have had separate nuclear talks, and cultural and religious visits by South Koreans to the North have resumed.

South Korean and U.S. officials, however, have demanded the North halt its uranium-enrichment program, freeze nuclear and missile tests and allow international nuclear inspectors back into the country before resuming negotiations.

The North Korean statement Wednesday accused the United States and its allies of "groundlessly" taking issue with the North's peaceful nuclear activities. They are "deliberately laying a stumbling block in the way of settling the nuclear issue on the Korean peninsula through dialogue and negotiations," the statement said.

Kim Yong-hyun, a professor at Seoul's Dongguk University, said the North's statement appeared aimed at applying pressure on Washington and the international community to rejoin the nuclear disarmament talks quickly. "North Korea is expected to step up its rhetoric," he said.

Also on Wednesday, Seoul's Unification Ministry said a South Korean official who recently traveled to the North to help monitor the distribution of flour by a civic group confirmed that the aid has reached North Korean children. There have been concerns as to whether North Korea diverts outside food aid to its military.

__

Associated Press writer Foster Klug contributed to this report from Busan, South Korea.

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/ap/20111130/ap_on_re_as/as_koreas_nuclear

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Tuesday, November 29, 2011

Business Owner Claims He Was Misled About Contract For Work ...

Businessman Peter Papageorge says he felt pressured to sign a contract for work-safety seminars. (CBS)

Businessman Peter Papageorge says he felt pressured to sign a contract for work-safety seminars. (CBS)

CHICAGO (CBS) -- A Chicago business owner claims he felt pressured into signing up for a service, and now he?s being sued for more than $17,000 to fulfill a contract.

Peter Papageorge says a Compsolve salesperson showed up unexpectedly at his business, Peco, Inc. The garment manufacturer says he was told federal work safety regulators are ?targeting? his industry.

?They put the fear of God in you,? Papageorge tells CBS 2?s Suzanne Le Mignot. ?They told me the initial smallest fine that OSHA charges is $7,000.?

Papageorge says he felt pressured into signing a contract for an OSHA compliance seminar. He paid about $4,000. Now, Papageorge is being sued by Compsolve for more than $17,000 to fulfill the contract?s training-renewal fee.

In a statement, Compsolve says it is within its legal rights.

?We are A + rated by the BBB,? the company says. ?This complaint stems from the fact that Mr. Papageorge is being sued by our company for breach of contract. That is why we have a court system in this country ? they can take all the evidence into account and decide who is in the right.?

CBS 2 found at least 48 civil suits filed by Compsolve against businesses, seeking payment. Twenty-eight of those companies are in Cook and Kane counties. The rest are in Florida and Michigan.

In response to those suits, Compsolve says, ?If a company breaches our contract, we are going to sue them.?

Compsolve?s website has positive testimonials, saying companies have received ?an excellent presentation? and that Compsolve is ?very professional and thorough.?

?I think they did a nice job of training us, but beyond that, that?s four and a half hours and I already paid $4,000,? Papageorge says. ?That?s all you?re getting from me because I don?t want other business people to have this happen to them.?

The state of Illinois offers a free OSHA inspection through the Department of Commerce and Economic Opportunity. If violations are found, the business is also allowed to correct those violations without any penalty.

The National Safety Council can also provide a list of agencies that can give advice about OSHA compliance. Meantime, the Better Business Bureau says Compsolve?s A-plus status in Buffalo, N.Y. was recently downgraded, pending complaint reviews.

Source: http://chicago.cbslocal.com/2011/11/28/business-owner-claims-he-was-misled-about-contract-for-work-safety-seminars/

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Video: Authors on growing up in a divided South (cbsnews)

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President brings daughters to bookstore to promote small-business holiday shopping (Star Tribune)

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Big expansion, big questions for Teach for America (AP)

MIAMI ? In a distressed neighborhood north of Miami's gleaming downtown, a group of enthusiastic but inexperienced instructors from Teach for America is trying to make progress where more veteran teachers have had difficulty: raising students' reading and math scores.

"These are the lowest performing schools, so we need the strongest performing teachers," said Julian Davenport, an assistant principal at Holmes Elementary, where three-fifths of the staff this year are Teach for America corps members or graduates of the program.

By 2015, with the help of a $50 million federal grant, program recruits could make up one-quarter of all new teachers in 60 of the nation's highest need school districts. The program also is expanding internationally.

That growth comes as many districts try to make teachers more effective. But Teach for America has had mixed results.

Its teachers perform about as well as other novice instructors, who tend to be less successful than their more experienced colleagues. Even when they do slightly better, there's a serious offset: The majority are out of the teaching profession within five years.

"I think ultimately the jury is out," said Tony Wagner, a professor at the Harvard Graduate School of Education, and an instructor to the first class of TFA corps members.

Teach for America teachers work with not just the poor, but also English language learners and special education students. They provide an important pipeline of new teachers. But critics cite the teachers' high turnover rate, limited training and inexperience and say they are perpetuating the same inequalities that Teach for America has set to eradicate.

"There's no question that they've brought a huge number of really talented people in to the education profession," said Kati Haycock, president of The Education Trust, which advocates on behalf of low-income and minority children, and a longtime supporter of TFA.

But, she said, "Nobody should teach in a high poverty school without having already demonstrated that they are a fabulous teacher. For poor kids, education has to work every single year."

___

Wendy Kopp started Teach for America while studying public policy at Princeton. For her senior thesis, she developed a plan to place top college graduates in the poorest schools. She sent the plan to dozens of Fortune 500 executives. Within a year, she had raised $2.5 million and had 2,500 applications.

Over the past 20 years, thousands of recent college graduates have taught for two years in some of the most challenging classrooms in hopes of helping close the achievement gap. Applications have doubled since 2008. Foundations have donated tens of millions.

With Teach for America's guidance, groups are being established in India, Chile and other places with deep educational inequalities.

Many countries, including those where students perform higher in math and reading, send the strongest and most experienced teachers to work with the lowest performing students. The U.S. has done the reverse. There are nearly twice as many teachers with fewer than three years' experience in schools where students are predominantly low income and minority.

Family income is one of the most accurate predictors of how well a student will perform. Just 18 percent of low-income eighth-grade students, for example, scored as proficient or above in reading on the 2011 National Assessment of Educational Progress.

"When we started this 20 years ago, the prevailing notion backed up by all the research was socio-economic circumstances determine educational outcomes," Kopp said in an interview with The Associated Press. "We've seen real evidence it does not have to be that way."

How to overcome the challenges of poverty is at the center of the debate over education reform, with an increasing focus on effective teaching.

Highly effective teachers are hardest to find at the least advantaged schools.

"The reality, particularly in urban centers in America, is they aren't there," said Tim Knowles, director of the Urban Education Institute at the University of Chicago, who served as the founding director for Teach for America in New York City.

___

Teach for America believes it can create a corps of such teachers in a short time.

Research, however, shows that beginning instructors improve with experience.

A Harvard study of students in Texas found that a teacher's level of education, experience, and scores on licensing exams have a greater influence on student performance than any other factor. North Carolina research on teacher training programs, including Teach for America, showed that elementary students taught math by a first-year teacher lose the equivalent of 21 days of schooling compared with students who had teachers with four years of experience.

If inexperienced teachers don't perform as well, then why pair them with students who struggle the most?

"When they started, we were staffing our high poverty schools ... with anything that breathed," said Haycock. But, she added, "Saying their solution is better than what came before it is not to say it's the right thing."

Wagner noted that his master's degree in teaching from Harvard hardly prepared him for the challenges of being a first-year teacher. "Unless and until we have a dramatically different system, and a universally high quality system for preparing teachers, I think TFA is a stop gap, and an important one," he said.

___

Most who apply for Teach for America have not studied education or thought about teaching, but consider it after speaking with a recruiter or program graduate.

For Ryan Winn, it was a picture of a recruiter's third-grade class in Phoenix that persuaded him to apply. The recruiter told him that half the students were expected to drop out by the eighth grade.

"That struck me as incredibly unfair and I was upset about it," said Winn, a teacher this year in Memphis, Tenn.

At Holmes Elementary in Miami, the classrooms of Teach for America teachers are filled with posters reminding students of the ambitious goals set for them.

"I have to make a change," said Michael Darmas, a first-year teacher at Holmes. "I have to make a difference."

Teach for America training starts with thick packages of readings and then five weeks co-teaching a summer class, usually in an urban school district, with students who have fallen behind and are taking remedial coursework in order to advance to the next grade.

The fledgling teachers are overseen by another instructor. That could be a more veteran public school teacher, or current or former Teach for America corps member.

"It was a real steep learning curve," said Sarahi Constantine Padilla, a recent Stanford University graduate teaching at Holmes.

When the summer is over, teachers are sent to their assigned districts, which pay up to $5,000 to Teach for America for each corps member they hire, in addition to the teacher's salary. Many don't find out exactly what they'll be teaching until shortly before school begins.

In interviews with nearly two dozen Teach for America corps members, many described classroom triumphs. Several also acknowledged feeling dubious about their abilities as first-year teachers.

"I struggled personally with my ability to be effective, and I think the gains my kids achieved were largely in spite of me," said Brett Barley, who taught in the San Francisco Bay area. "I thought the key thing I was able to bring to them was communicating the urgency of the predicament they faced and having them buy in to the idea they could be successful."

Most of the fourth-graders Barley taught entered reading and writing at second-grade levels. About 30 percent weren't native English speakers; two were classified as blind.

"The biggest challenge was trying to learn on the job to meet all the kids at their different skill levels," Barley said.

In her book, "A Chance to Make History," Kopp tells the stories of several Teach for America teachers who achieved remarkable success in the classroom. But it's not hard to find teachers who come out with a very different story about their experience.

Megan Hopkins, a Spanish major in college who was placed in Phoenix as a bilingual teacher, said she did not receive any training on teaching English language learners.

"I had no idea how to teach a child to read," Hopkins said. "I had no idea how to teach a second language learner to read in Spanish, much less in English. After five weeks of training, I really had no idea what I was doing. I felt that was a big disservice to my students."

Teach for America encouraged her to set a goal of advancing her students 1 1/2 grade levels. She didn't know how to go about building such a measurement, but was able to develop one with other teachers.

Hopkins said she was praised "up and down" for increasing student reading levels, but she questioned the results. One student, a native Spanish speaker, could read fluently in English, "but if you asked him what he read, he had absolutely no idea."

___

Teach for America, in its own review of external research, concludes that its teachers achieve student gains that are "at least as great as that of other new teachers." In some studies they do better, and in others they do worse.

Teach for America gathers information on how its teachers are performing, but does not release any data to the public. "We just don't feel it's responsible to show," Kopp said. "There are so many flaws in our system."

One consistent finding is Teach for America's high turnover rate. According to the organization, 33 percent of its graduates are still teaching. But in many districts, retention rates are significantly lower. A study published last year from North Carolina, for example, found that after five years, 7 percent of Teach for America corps members were still teaching in the state.

Kopp and others at Teach for America note turnover rates are high across low-income schools. But among teacher preparation programs, Teach for America has one of the highest.

She said requiring a two-year commitment is critical to attracting high quality candidates. The main reason Teach for America teachers leave the classroom, Kopp said, is because they want to have a bigger impact. Sixty percent of the program's graduates are still working in education, whether it's in policy, or for a nonprofit or government agency, according to TFA.

Throughout their time with Teach for America, corps members are frequently told about the organization's "theory of change." It's the idea that, no matter what field they ultimately enter, they will remain committed to fixing educational inequalities.

Many of the graduates interviewed for this story did leave teaching.

Hopkins, the Phoenix teacher, earned a doctorate in education and has focused much of her research on English language learners.

"But what if their theory of change would encourage their teachers to stay in the classroom as a form of change, as a form of leadership in the field of education?" she asked.

___

At Holmes Elementary, much is at stake.

If the state isn't granted a waiver from the federal education law known as No Child Left Behind, the school could close unless it significantly improves math and reading scores on Florida's standardized assessment.

"I like the pressure," said third-grade teacher Daniel Guerrero. "It makes me want to stay up late and make sure everything is ready."

Assistant Superintendent Nikolai Vitti says clustering Teach for America teachers together has worked in other district schools and he hopes to attract more beyond their two-year commitment.

Davenport, the assistant principal and a program alumnus, said that will depend on whether corps members feel valued.

"If they don't feel that opportunity to exercise their abilities," he said, "they won't be compelled to stay."

___

Online:

Teach for America: http://www.teachforamerica.org

Education Trust: http://www.edtrust.org

National Assessment of Educational Progress: http://nces.ed.gov/nationsreportcard

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20111127/ap_on_re_us/us_teach_for_america

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Monday, November 28, 2011

Scrambling to compete?

Please tell me which way Apple is going so I can try to race ahead!


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Sunday, November 27, 2011

Richardson powers No. 2 Bama past Auburn, 42-14

Alabama quarterback AJ McCarron (10) reacts after throwing a touchdown against Auburn during the first half of an NCAA college football game in Auburn, Ala., Saturday, Nov. 26, 2011. (AP Photo/Dave Martin)

Alabama quarterback AJ McCarron (10) reacts after throwing a touchdown against Auburn during the first half of an NCAA college football game in Auburn, Ala., Saturday, Nov. 26, 2011. (AP Photo/Dave Martin)

Auburn coach Gene Chizik looks down after Alabama stopped Auburn on fourth down during the second half of Alabama's 42-14 win in an NCAA college football game Saturday, Nov. 26, 2011, in Auburn, Ala. (AP Photo/Butch Dill)

Alabama running back Trent Richardson (3) looks on before an NCAA college football game against Auburn at Jordan-Hare Stadium in Auburn, Ala., Saturday, Nov. 26, 2011. (AP Photo/Butch Dill)

Auburn tight end Philip Lutzenkirchen looks up at the scoreboard as Alabama pulls away to defeat Auburn 42-14 during the second half of an NCAA college football game Saturday, Nov. 26, 2011, in Auburn, Ala. (AP Photo/Butch Dill)

Alabama linebacker Courtney Upshaw (41) sacks Auburn quarterback Kiehl Frazier (10) during the second half of an NCAA college football game Saturday, Nov. 26, 2011, in Auburn, Ala. Alabama won 42-14. (AP Photo/Butch Dill)

(AP) ? Trent Richardson and No. 2 Alabama have convinced Nick Saban that they're worthy of competing for college football's top prize.

They'll have to wait a while before for the final decision is rendered.

Richardson rushed for a career-high 203 yards and AJ McCarron threw three first-half touchdown passes to lift Alabama to a 42-14 victory over rival Auburn on Saturday in what amounted to a statement game.

Let the lobbying begin. Saban said he thinks the Tide is one of the nation's best two teams, Richardson's the top player and 'Bama deserves a second shot at LSU.

"This team lost one game in overtime to a very, very good team who's No. 1 right now," the Tide coach said. "And we lost in overtime. Everybody's got to make their choices and decisions about that.

"But I think we've got a great football team and a great bunch of young men who have done a wonderful job and played some really dominant football on both sides of the ball. I think they deserve an opportunity, the best opportunity that's out there for them."

The Tide (11-1, 7-1 Southeastern Conference) has a week before finding out if its resume is good enough to secure a shot at a second national title in three years. No. 5 Oklahoma State, fourth in the BCS standings, and No. 1 LSU have big games remaining against No. 12 Oklahoma and No. 13 Georgia, respectively.

"That's out of our hands but I think we've proven we should be there without a doubt," said Alabama tight end Brad Smelley, who had six catches for 86 yards and a touchdown.

Richardson ran 27 times and caught a 5-yard touchdown pass in his final chance to impress Heisman voters. He had runs of 35 and 57 yards to set up second-half scores.

"To me, Trent's the best football player in the country," Saban said.

The thousands of 'Bama faithful in the stands seemed to agree.

Fans began chanting first "Heisman" and then "LSU" in the fourth, with a sizable contingent wearing crimson and white remaining in the stands afterward clamoring for a rematch. By then, there wasn't all that much orange and blue left.

The Tide fell to LSU 9-6 in an overtime game that 'Bama fans at least feel didn't settle the matter of which one is better.

Richardson said he'd already gotten a call from LSU star Russell Shepard saying "See you in New Orleans" for the title game.

Even if the national picture remains fuzzy, it's pretty clear which is the best team in the state.

In the end, the win might have given the Tide enough style points to hold onto No. 2 in the BCS rankings whatever happens next week.

"We knew coming in that, hey, if you want to be in the national championship again ? we deserve to be in it ? we had to take care of business," McCarron said. "And that's what we did."

The Tide dominated statistically but didn't put Auburn (7-5, 4-4) away until Dee Milliner's 35-yard interception return early in the fourth quarter. Alabama entered the quarter with a 309-44 advantage in total yards but also gave up touchdowns on a fumble recovery and a kick return.

McCarron completed 18 of 23 passes for 184 yards but only attempted five second-half passes. Richardson handled the rest. He gained 142 yards on 13 carries in the second half against a defense ranked 98th nationally against the run.

"Any time you've got No. 3 in your backfield, a team's going to challenge you," McCarron said.

The result was more than enough to end Auburn's streak of 14 straight wins at Jordan-Hare Stadium.

"I've got a locker room full of guys right now and coaches that are hurting and a lot of fans that are hurting as well," Tigers coach Gene Chizik said. "So this is a tough day.

"We wanted to keep the game close in the fourth quarter and have a chance to win the game. We got to the fourth quarter and felt like we were somewhere in that ballpark, and the fourth quarter got away from us. We kind of self-destructed."

The Tigers' biggest offensive weapons were mostly nonfactors. Tailback Mike Dyer, the SEC's No. 2 rusher, had three carries at the half and finished with 13 for 48 yards.

Clint Moseley completed 11 of 18 passes for a paltry 62 yards and the pick-6. Freshman backup Kiehl Frazier played much of the game but didn't complete either of his two pass attempts.

"It was the best defense we've played against this year," Moseley said. "I feel pretty confident saying that."

The Tigers did threaten an offensive touchdown in the fourth but stalled on downs after getting it to the 5. Then Richardson scampered down the left sideline and sprinted to the other side of the field for the 57-yarder.

Auburn managed to hang around for three quarters. Then Milliner intercepted a badly overthrown pass by Moseley, who has now had three passes returned for TDs in Auburn's three biggest games against LSU, Georgia and Bama.

All those were blowouts but Chizik said his team wasn't having flashbacks.

"It wasn't here we go again," he said. "It was just let's keep fighting and let's keep playing and let's get this thing in the fourth quarter and keep it close enough where we could win it."

The two-point play made it 35-14, and Auburn couldn't come close to a second straight huge Iron Bowl comeback.

Like last season, Alabama led 24-7 at the half. This time the Tigers didn't have Cam Newton pulling the trigger on a comeback en route to a Heisman and a national title.

Auburn struck instantly in the second half. Onterio McCalebb returned the opening kick 83 yards for a touchdown, the Tigers' first score on a kick return in Iron Bowl history.

The Tigers then held Alabama to a field goal and converted a fourth-and-1 near midfield but couldn't sustain the momentum change.

Auburn followed it up with a fumbled pitch for a 10-yard loss, a penalty and a lateral to Frazier, who badly overthrew a receiver deep.

Alabama outgained the Tigers 397-140 and held Auburn to 3 of 15 on third downs.

"Our goal today was to play our best football game," Saban said. "We went out and played the best we could play. I'm satisfied with what our players did from that standpoint."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-11-26-FBC-T25-Alabama-Auburn/id-ad95c55ba6ae413eaa106aa1356bc96a

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